MAPI over HTTP question

Hi,

We have a single Exchange Organization consisting of 2 domains with separate Exchange services per domain. The parent domain servers are all at Exchange 2010 while the subdomain has been migrated to Exchange 2013 and all the Exchange 2010 servers have been decommissioned. I was looking at implementing MAPI over HTTP for the subdomain (which is Exchange 2013), however since part of the process involves a global setting (Set-OrganizationConfig -MapiHttpEnabled $true) I am concerned that this might impact the parent domain which is at Exchange 2010.

Any ideas?

Thank you.