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Intermitent Receive Errors

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Good Evening,

I am running into an Intermittent receive error on Exchange 2013 RU 8 on Windows 2012.  Messages will randomly error with :

 The server returned status code 451 - Error in processing. The server response was: 4.7.0 Temporary server error. Please try again later. PRX5
Exception details:
Message: Error in processing. The server response was: 4.7.0 Temporary server error. Please try again later. PRX5
Type: System.Net.Mail.SmtpException
Stack trace:
at System.Net.Mail.DataStopCommand.CheckResponse(SmtpStatusCode statusCode, String serverResponse)
at System.Net.Mail.DataStopCommand.Send(SmtpConnection conn)
at System.Net.Mail.SmtpClient.Send(MailMessage message)
at Microsoft.Exchange.Tools.ExRca.Tests.SmtpMessageTest.PerformTestReally()

Elapsed Time: 21538 ms. 

Exchange receive logs show the following:

mail.hulbertassociates.com Microsoft ESMTP MAIL service ready at <RegionalDay-Date-24HourTimeFormat> <RegionalTimeZoneOffset>,



EHLO www.testexchangeconnectivity.com,



SMTPSubmit SMTPAcceptAnySender SMTPAcceptAuthoritativeDomainSender AcceptRoutingHeaders,Set Session Permissions



250-mail.hulbertassociates.com Hello [157.56.138.143],



250-SIZE 104857600,



250-PIPELINING,



250-DSN,



250-ENHANCEDSTATUSCODES,



250-STARTTLS,



250-AUTH NTLM,



250-8BITMIME,



250-BINARYMIME,



250 CHUNKING,



MAIL FROM:<Admin@TestExchangeConnectivity.com>,



SMTPSubmit SMTPAcceptAnySender SMTPAcceptAuthoritativeDomainSender AcceptRoutingHeaders,Set Session Permissions



receiving message



250 2.1.0 Sender OK,



RCPT TO:<jparks@hulbertassociates.com>,



250 2.1.5 Recipient OK,



DATA,



354 Start mail input; end with <CRLF>.<CRLF>,



Proxy destination(s) obtained from OnProxyInboundMessage event



Message or connection acked with status Retry and response 441 4.4.1 Error encountered while communicating with primary target IP address: ""Failed to connect. Winsock error code: 10060, Win32 error code: 10060."" Attempted failover to alternate host, but that did not succeed. Either there are no alternate hosts, or delivery failed to all alternate hosts. The last endpoint attempted was 65.102.233.138:2525"



451 4.7.0 Temporary server error. Please try again later. PRX5 ,



Remote(SocketError)

I am at a loss at the moment.  Any suggestions would be appreciated.



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