I Need Support to update exchange 2013 CU10

Hi Guys,

My environment:

1. Domain Controller ( DNS / ADDS / DHCP )

2. Exchange Server 2013 only

i newly install exchange 2013 on my server 

then i try to update to CU10 im getting error 

error:

An attempt was made to load an assembly from a network location which would have caused the assembly to be sandboxed in previous version of the .net framework. this release of the .net framework dose not enable CAS policy by default, so this load may be dangerous , if this load is not intended to sandbox the

after words i can't see